STI Prevention: Comprehensive Strategies
Evidence-based approaches to reduce your risk of sexually transmitted infections and protect your sexual health.
Medically reviewed by healthcare professionals
Last updated: April 2025
Understanding STI Prevention
Sexually transmitted infections (STIs) are common, but they're also largely preventable. Effective prevention requires a multi-faceted approach that includes education, communication, testing, and using appropriate protection methods.
Key Prevention Principles
- No single method is 100% effective (except abstinence)
- Combining methods (like condoms plus regular testing) provides better protection
- Consistent use of prevention methods is crucial
- Communication with partners is an essential component of prevention
- Regular testing helps detect infections early, preventing further transmission
Barrier Methods
Barrier methods are physical devices that prevent direct contact between bodily fluids and potentially infected skin or mucous membranes during sexual activity.
External (Male) Condoms
When used consistently and correctly, external condoms are highly effective at preventing many STIs, including HIV, chlamydia, gonorrhea, and trichomoniasis.
Effectiveness:
- 98% effective at preventing HIV transmission when used correctly
- Highly effective against fluid-transmitted STIs
- Provides partial protection against STIs transmitted through skin-to-skin contact
Proper Usage Tips:
- Check the expiration date and ensure the package is intact
- Use a new condom for each sex act
- Put the condom on before any genital, oral, or anal contact
- Leave space at the tip to collect semen
- Unroll completely to the base
- Hold the rim when withdrawing after ejaculation
- Use only water-based or silicone-based lubricants with latex condoms
Common Mistakes to Avoid
- Using expired condoms
- Using oil-based lubricants with latex condoms
- Putting on the condom inside-out
- Not leaving space at the tip
- Using teeth or sharp objects to open the package
- Re-using condoms
- Storing condoms in wallets or hot places
Internal (Female) Condoms
Internal condoms are inserted into the vagina or rectum before sexual contact. They give the receptive partner control over protection.
Advantages:
- Can be inserted up to 8 hours before sexual activity
- Covers more external genital area, potentially offering better protection against STIs transmitted through skin contact
- Can be used with oil-based lubricants
- Made of nitrile, so safe for people with latex allergies
Proper Usage Tips:
- Remove the condom from packaging carefully
- Hold the inner ring and squeeze it between your fingers
- Insert the compressed ring into the vagina or anus
- Push the inner ring up as far as it will go
- The outer ring should remain outside the body
- Guide the penis or sex toy into the condom, not beside it
- After sex, twist the outer ring to contain fluids and gently pull out
Dental Dams
Dental dams are thin sheets of latex or polyurethane that provide a barrier between the mouth and vagina or anus during oral sex.
Usage:
- Place the dam over the vulva or anus before oral contact
- Hold the dam in place during oral sex
- Use a new dam if you switch from oral-anal to oral-vaginal contact
- Never reuse or flip over a used dental dam
If commercial dental dams aren't available, you can make one from an external condom by:
- Carefully unroll the condom
- Cut off the tip and cut along one side to create a rectangular sheet
- Place this over the genital or anal area for oral sex
Medical Prevention Methods
Medical interventions can significantly reduce the risk of acquiring or transmitting STIs.
Vaccinations
Safe and effective vaccines are available for certain STIs:
HPV (Human Papillomavirus) Vaccine
- Protects against strains of HPV that cause most cervical cancers, as well as many anal, penile, vaginal, vulvar, and oropharyngeal cancers
- Also protects against strains that cause most genital warts
- Recommended for all adolescents starting at age 11-12, but can be given through age 26
- Some adults ages 27-45 who weren't previously vaccinated might benefit from HPV vaccination after discussing with their healthcare provider
Hepatitis B Vaccine
- Protects against hepatitis B virus, which can be transmitted sexually
- Typically given as a series of 3-4 shots over 6 months
- Recommended for all infants, unvaccinated children and adolescents, and unvaccinated adults at risk
Hepatitis A Vaccine
- Protects against hepatitis A virus, which can be transmitted through certain sexual practices
- Particularly recommended for men who have sex with men and people with multiple partners
- Usually given as 2 shots, 6 months apart
Note
These vaccines are most effective when given before any exposure to the viruses. However, they may still provide some benefit even if you've already been exposed. Consult your healthcare provider about which vaccines might be appropriate for you.
Pre-Exposure Prophylaxis (PrEP)
PrEP is a medication taken by HIV-negative individuals to prevent HIV infection.
Key Information:
- When taken as prescribed, PrEP reduces the risk of getting HIV from sex by about 99%
- Available as a daily pill or, in some cases, as an injection every two months
- Requires regular medical check-ups, typically every 3 months
- Does NOT protect against other STIs or pregnancy
- Most effective when combined with other prevention methods, such as condoms
Who Should Consider PrEP:
- Men who have sex with men and engage in high-risk behaviors
- Transgender individuals who engage in high-risk behaviors
- Heterosexual men and women who have high-risk factors
- People who inject drugs
- People in relationships with HIV-positive partners
Important Note
PrEP must be prescribed by a healthcare provider, who will conduct HIV testing and other assessments to determine if PrEP is appropriate. Insurance coverage and assistance programs are available to help cover the cost.
Post-Exposure Prophylaxis (PEP)
PEP is an emergency intervention to prevent HIV infection after a potential exposure.
Key Points:
- Must be started within 72 hours (3 days) of possible exposure, ideally as soon as possible
- Consists of a 28-day course of antiretroviral medications
- Available through emergency rooms, urgent care clinics, or some healthcare providers
- Not intended for regular use as a prevention strategy
Consider PEP if:
- You had unprotected sex with someone who is HIV-positive or whose HIV status is unknown
- You experienced sexual assault
- You shared needles or other injection equipment
- You experienced a condom breakage with a partner whose HIV status is positive or unknown
Important
PEP is an emergency intervention. If you think you need PEP, seek medical attention immediately. Do not wait.
Regular Testing and Early Treatment
Regular testing is a crucial component of STI prevention, as it allows for early detection and treatment, preventing both complications and further transmission.
Recommended Testing Schedule:
Who | How Often | What Tests |
---|---|---|
Sexually active women under 25 | Annually | Chlamydia and gonorrhea |
Sexually active women 25+ with risk factors* | Annually | Chlamydia and gonorrhea |
Pregnant women | First prenatal visit | HIV, syphilis, hepatitis B, chlamydia, gonorrhea |
Men who have sex with men (MSM) | At least annually, every 3-6 months if high risk | HIV, syphilis, chlamydia, gonorrhea (rectal and/or pharyngeal if exposed) |
Everyone age 13-64 | At least once | HIV |
People with HIV | At diagnosis and then periodically | Comprehensive STI screening |
People who share injection equipment | Periodically | HIV, hepatitis B, hepatitis C |
*Risk factors include new or multiple sex partners, a sex partner with concurrent partners, a sex partner with an STI, inconsistent condom use among people not in mutually monogamous relationships.
Types of Tests Available
- Urine tests - For chlamydia, gonorrhea
- Blood tests - For HIV, syphilis, hepatitis B and C
- Swab tests - Samples from the genital, rectal, or throat areas for various STIs
- Physical examinations - For visible symptoms like warts, herpes lesions
- Home testing kits - Available for several STIs, including HIV and chlamydia
Early Treatment Benefits:
- Prevents complications - Early treatment can prevent serious health issues like pelvic inflammatory disease or infertility
- Reduces transmission - Treating infections promptly reduces the chance of passing them to partners
- Shortens infectious period - Many STIs become non-transmissible after appropriate treatment
- Partner notification - Early diagnosis allows for timely notification of partners who may also need testing and treatment
Communication and Behavioral Strategies
Effective communication and behavioral choices play a significant role in STI prevention.
Partner Communication
Open, honest communication with sexual partners is essential for STI prevention:
Discussion Topics:
- STI testing history and status
- Sexual history and risk factors
- Prevention methods you prefer to use
- Boundaries and consent
- Monogamy expectations or agreements about other partners
Tips for Effective Conversations:
- Choose a private, comfortable setting
- Have the conversation before becoming intimate
- Be honest and direct, but non-judgmental
- Use "I" statements to express your needs
- Listen actively to your partner's perspective
- Be prepared with information about testing resources
Risk Reduction Behaviors
Certain behavioral choices can significantly reduce your risk of STIs:
- Limiting sexual partners - Having fewer partners reduces exposure risk
- Mutual monogamy - Having sex only with one person who only has sex with you
- Delayed sexual debut - Postponing first sexual experience until older
- Regular screening - Getting tested between partners
- Reducing substance use - Avoiding alcohol or drugs before sex, as they can impair judgment and reduce likelihood of using protection
- Considering lower-risk sexual activities - Some sexual activities carry less STI risk than others
Understanding Risk Levels of Different Activities:
Risk Level | Activities |
---|---|
No Risk | Abstinence, masturbation, virtual sex, non-sexual physical affection |
Lower Risk | Kissing, manual stimulation (hand-to-genital contact), properly protected oral, vaginal, or anal sex |
Higher Risk | Unprotected oral, vaginal, or anal sex, sharing sex toys without cleaning |
STI Prevention in Special Circumstances
During Pregnancy
Preventing STIs during pregnancy is particularly important as infections can affect both maternal and fetal health:
- Get comprehensive STI testing at your first prenatal visit
- Continue using condoms during pregnancy if you or your partner has other partners
- Consider repeat testing in the third trimester if you're at increased risk
- Discuss any symptoms with your healthcare provider immediately
- Ensure any diagnosed STIs are treated promptly with pregnancy-safe medications
For Adolescents and Young Adults
Young people aged 15-24 account for half of all new STI cases. Prevention strategies for this age group include:
- Comprehensive sexual education
- Access to confidential healthcare services
- Learning about consent and healthy relationships
- Annual screening if sexually active
- HPV vaccination
- Open communication with trusted adults
In Long-term Relationships
Even in long-term relationships, STI prevention remains important:
- Get tested together before stopping condom use
- Discuss and agree on monogamy expectations
- Consider periodic testing if either partner has outside sexual contacts
- Maintain open communication about sexual health
- Consider barriers if either partner has a chronic STI like herpes or HIV
Sources & References
1. Centers for Disease Control and Prevention. (2022). Sexually Transmitted Infections Treatment Guidelines, 2021.
2. World Health Organization. (2022). Sexually transmitted infections (STIs) prevention.
3. American Sexual Health Association. (2022). STI Prevention.
4. U.S. Preventive Services Task Force. (2021). Screening for Chlamydia and Gonorrhea: Recommendation Statement.
5. Mayo Clinic. (2022). Sexually transmitted diseases (STDs) - Prevention.
6. Journal of Sexually Transmitted Diseases. (2021). Advances in STI Prevention.
7. UNAIDS. (2022). HIV Prevention.